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Roxadustat - Powder (1.5g)

Roxadustat - Powder (1.5g)

Regular price €28.00 EUR
Regular price €32.00 EUR Sale price €28.00 EUR
Sale Sold out
Tax included. Shipping calculated at checkout.
Containers oversized for now so a discount is applied.
• High quality reference material (≥98% Purity)
• Lowest price on the market
• Contains 1.5g Roxadustat as powder
• Estimated 30-45 days of research supply

This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

Description

Summary

Roxadustat is a synthetic compound classified as a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI). It is not naturally occurring and is designed to boost red blood cell production through specific mechanisms. Roxadustat works by inhibiting prolyl hydroxylase enzymes (PHD1, PHD2, PHD3), which normally target hypoxia-inducible factor α (HIF-α) for breakdown [1]. This inhibition stabilizes HIF-α, enabling it to trigger genes that increase erythropoietin (EPO) production, essential for red blood cell formation. It’s notably present in research involving oxygen regulation, as outlined in studies like one from the New England Journal of Medicine [2].

Alongside EPO, roxadustat enhances iron availability by regulating genes such as transferrin and ferroportin, while also lowering hepcidin levels, which typically limit iron use [3]. This combination of effects distinguishes it among HIF-PHIs, offering a potent approach to oxygen-related processes. Additionally, it shows promise in broader applications, with early studies exploring its impact on hypoxia-related conditions like myelodysplastic syndromes [4]. Roxadustat’s oral delivery and targeted action make it a novel tool in biochemical research.

Analysis

Pending 

Pharmacology

Other Names

Roxadustat, FG-4592, FG4592

Status Phase 3
Pubchem CID https://pubchem.ncbi.nlm.nih.gov/compound/11256664
CAS Number 808118-40-3
IUPAC Name 2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
Molecular Formula C19H16N2O5
Smiles CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3

Attributes

Total Product Weight 30g
Product Form 1.5g in plastic container (does not include scoop)
Physical Form White-gray powder
Container Dimensions ?
$/g (Cost Per Gram) 1.8$

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