Roxadustat - Powder (1.5g)
Roxadustat - Powder (1.5g)
• High quality reference material (≥98% Purity)
• Lowest price on the market
• Contains 1.5g Roxadustat as powder
• Estimated 30-45 days of research supply
This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.
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Description
Summary
Roxadustat is a synthetic compound classified as a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI). It is not naturally occurring and is designed to boost red blood cell production through specific mechanisms. Roxadustat works by inhibiting prolyl hydroxylase enzymes (PHD1, PHD2, PHD3), which normally target hypoxia-inducible factor α (HIF-α) for breakdown [1]. This inhibition stabilizes HIF-α, enabling it to trigger genes that increase erythropoietin (EPO) production, essential for red blood cell formation. It’s notably present in research involving oxygen regulation, as outlined in studies like one from the New England Journal of Medicine [2].
Alongside EPO, roxadustat enhances iron availability by regulating genes such as transferrin and ferroportin, while also lowering hepcidin levels, which typically limit iron use [3]. This combination of effects distinguishes it among HIF-PHIs, offering a potent approach to oxygen-related processes. Additionally, it shows promise in broader applications, with early studies exploring its impact on hypoxia-related conditions like myelodysplastic syndromes [4]. Roxadustat’s oral delivery and targeted action make it a novel tool in biochemical research.
Analysis
Pharmacology
| Other Names |
Roxadustat, FG-4592, FG4592 |
| Status | Phase 3 |
| Pubchem CID | https://pubchem.ncbi.nlm.nih.gov/compound/11256664 |
| CAS Number | 808118-40-3 |
| IUPAC Name | 2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid |
| Molecular Formula | C19H16N2O5 |
| Smiles | CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3 |
Attributes
| Total Product Weight | 30g |
| Product Form | 1.5g in plastic container (does not include scoop) |
| Physical Form | White-gray powder |
| Container Dimensions | ? |
| $/g (Cost Per Gram) | 1.8$ |
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