PBIO-4D - Solution (20mg/mL)
PBIO-4D - Solution (20mg/mL)
• Penchant Bio Exclusive
• Contains 300mg PBIO-4D (15mL)
• Estimated 30-40 days of research supply
This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.
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Description
Summary
PBIO-4D (also known as BPN14770) is a selective PDE4D NAM (Negative Allosteric Modulator) that targets long-form PDE4D enzyme isoforms [-3,-7]. It's selectivity over other PDE4 subtypes and short-form PDE4D is what makes it more tolerable in literature testing than unselective PDE4 inhibitors, not having the same emesis and offtarget risks.
Based on literature [1], it is a potent spatial cognitive enhancer, increasing spatial cognitive measures in healthy Cynomolgus Monkeys and also improving cognitive endpoints in phase trials.
The compound has been well tolerated in its phase trials, with a low incidence of side effects being reported. No serious adverse events have been reported and it has been successful in multiple phase trials for Fragile X.
It also has a favorable pharmacological profile, being relatively potent and with a favorable half life of approximately 10-12 hours.
It is soluble in PEG-400 and DSMO up to 80mg/mL, with poor solubility in water. It can be stored up to 2 years with proper storage.
For more information on the pharmacology of PBIO-4D and PDE4D inhibition, you can visit this post.
Analysis
Pharmacology
| Other Names | BPN14770, BPN-14770, D159797, BPN-14470 (common typo) |
| Status | Phase 2B |
| Pubchem CID | 90111638 |
| CAS Number | 1606974-33-7 |
| IUPAC Name | 2-[4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl]phenyl]acetic acid |
| Molecular Formula | C21H15ClF3NO2 |
| Smiles | C1=CC(=CC(=C1)Cl)C2=NC(=CC(=C2)CC3=CC=C(C=C3)CC(=O)O)C(F)(F)F |
| Half-Life | ~10 hours |
Attributes
| Total Product Weight | 65g |
| Product Form (Approximate, TBD) | 15ml ±5% in 15/30ml Bottle (includes measured dropper) |
| Physical Form | Liquid, solved in AR Grade PEG-400. |
| Bottle Dimensions | 33x100mm |
| $/g (Cost Per Gram) | TBD |
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