TAK-653 - Solution (4mg/mL)
TAK-653 - Solution (4mg/mL)
• Lowest price on the market for 30ml
• Contains 60/120mg TAK-653 (4mg/ml)
• Estimated 30/60 days of research supply (15/30ml)
This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.
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Description
Summary
TAK-653 (also known as 9E3TOE5RIZ) is a selective AMPA PAM (Positive Allosteric Modulator) that targets the same pathway as some notable racetams but with higher selectivity and without agonist affinity. The compound has been developed by Takeda (Millennium Pharmaceuticals, Inc.) for treatment-resistant depression, however comparitively, its effect on spatial cognition is more significant and interesting.
Studies have shown that TAK-653 can cross the blood-brain barrier and increase corticospinal excitability in both rats and humans. In addition, it has been shown to improve cognitive functions in multiple domains in rats and working memory in monkeys.
In one study on humans, TAK-653 improved the participants performance on the stroop test, which is indicative of spatial cognitive function.
In terms of side effects, TAK-653 has been well tolerated in studies, with a low incidence of side effects being reported. There were no serious adverse events reported and no participants withdrew from the studies due to adverse events. It also has a good pharmacological profile, being very potent at low doses and with a favorable half life of approximately 10 hours.
30ml may arrive as two seperate bottles depending on supply.
Analysis
Pharmacology
| Other Names | TAK-653, TAK653, Osavampator, UNII-9E3TOE5RIZ, CHEMBL4594403, MS-26031, HY-115864 |
| Status | Passed Phase 1 |
| Pubchem CID | 56655833 |
| CAS Number | 1358751-06-0 |
| IUPAC Name | 9-(4-cyclohexyloxyphenyl)-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide |
| Molecular Formula | C19H23N3O3S |
| Smiles | CC1=CN2CCS(=O)(=O)N=C2C(=N1)C3=CC=C(C=C3)OC4CCCCC4 |
Attributes
| Total Product Weight | 65-81g |
| Product Form | 15ml/30ml ±5% in 30ml Bottle (includes measured dropper) |
| Physical Form | Liquid, solved in PEG-400 (100%) |
| Bottle Dimensions | 33x100mm |
| $/g (Cost Per Gram) | 541-583$ |
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